Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and meta-analysis.
نویسندگان
چکیده
OBJECTIVES Exposure to passive smoke is a common and avoidable risk factor for wheeze and asthma in children. Substantial growth in the prospective cohort study evidence base provides an opportunity to generate new and more detailed estimates of the magnitude of the effect. A systematic review and meta-analysis was conducted to provide estimates of the prospective effect of smoking by parents or household members on the risk of wheeze and asthma at different stages of childhood. METHODS We systematically searched Medline, Embase, and conference abstracts to identify cohort studies of the incidence of asthma or wheeze in relation to exposure to prenatal or postnatal maternal, paternal, or household smoking in subjects aged up to 18 years old. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated by using random effects model. RESULTS We identified 79 prospective studies. Exposure to pre- or postnatal passive smoke exposure was associated with a 30% to 70% increased risk of incident wheezing (strongest effect from postnatal maternal smoking on wheeze in children aged ≤2 years, OR = 1.70, 95% CI = 1.24-2.35, 4 studies) and a 21% to 85% increase in incident asthma (strongest effect from prenatal maternal smoking on asthma in children aged ≤2 years, OR = 1.85, 95% CI = 1.35-2.53, 5 studies). CONCLUSIONS Building upon previous findings, exposure to passive smoking increases the incidence of wheeze and asthma in children and young people by at least 20%. Preventing parental smoking is crucially important to the prevention of asthma.
منابع مشابه
Effect of Active and Passive Exposure to Cigarette Smoke on Lipid Profile of Children and Adolescents; A Systematic Review and Meta-Analysis
Background: The present systematic review and meta-analysis is designed in order to assess the association between passive and active smoking and lipid profile of children and adolescents. Materials and Methods: An extensive search was done in databases of Medline, EMBASE, Web of Science, Scopus and CINAHL until October 2017. Two independent researchers screened articles and in the next step, ...
متن کاملCorrelation between cigarette smoke exposure and prevalence of asthma and allergy symptoms in children, Yazd
Introduction: Cigarette smoke is one of the most prevalent pollutants. Regarding the development of lungs and immune system at early stages of life, exposure to these substances can have adverse effects in this period. It seems that tobacco smoke is not an etiology for wheezing attacks burden, instead, it is an exacerbating factor. This survey was designed to determine the relation of environme...
متن کاملSerum, hair and nail Zinc level in children with asthma; zinc supplemental treatment in children with asthma: a systematic and meta-analysis review article
متن کامل
Socio-demographic characteristics of passive smokers exposed to environmental tobacco smoke and the influence of community-based interventions on its reduction in Isfahan, Najaf Abad and Arak
Introduction: Environmental tobacco smoke (ETS) inhaled by passive smokers cause health problems such as lung cancer, ischemic heart disease and asthma in adults and sudden infant death syndrome (SIDS), asthma, fetal growth retardation and neurodevelopment problems in children. The goal of this study was to determine socio-demographic characteristics of passive smokers exposed to ETS and evalua...
متن کاملAssociation between Environmental Dioxin-Related Toxicants Exposure and Adverse Pregnancy Outcome: Systematic Review and Meta-Analysis.
Dioxin-related compounds are associated with teratogenic and mutagenic risks in laboratory animals, and result in adverse pregnancy outcomes. However, there were inconsistent results in epidemiology studies. In view of this difference, we conducted a systematic review and meta-analysis to examine this association and to assess the heterogeneity among studies. Comprehensive literature searches w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Pediatrics
دوره 129 4 شماره
صفحات -
تاریخ انتشار 2012